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KMID : 1151920190010040152
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Chronobiology in Medicine
2019 Volume.1 No. 4 p.152 ~ p.156
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Comparison of Morning and Evening/Night Dosing on the Efficacy of Escitalopram in Major Depressive Disorder at Naturalistic Setting
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Han Kyu-Man
Yoon Ho-Kyoung
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Abstract
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Objective: Recent epidemiological and clinical studies have revealed that timing medications to the individual’s biological clock could improve their effectiveness and reduce side effects. We aimed to investigate the association of escitalopram dosing time with treatment response and changes in global depressive and insomnia symptoms after 8-week of antidepressant treatment in a naturalistic setting in patients with major depressive disorder (MDD).
Methods: A total of 71 patients with MDD taking escitalopram were recruited from the outpatient psychiatric clinic in a university hospital. The severity of depressive symptoms of all patients was assessed using the 17-item Hamilton Depression Rating Scale (HDRS) at the baseline and 8-week after the antidepressant treatment. The patients were classified into the Morning or Evening/Night group according to their time of escitalopram single dose.
Results: The time of escitalopram single dose (morning vs. evening/night) was not associated with treatment response after 8-week of treatment when controlling for potential confounding factors in patients with MDD. No significant difference in changes in total HDRS score and insomnia-related subscale score was observed between the Morning and Evening/ Night groups.
Conclusion: The present study suggests that the time of escitalopram single dose did not affect the treatment response or changes in global depressive and insomnia symptoms after 8-week of antidepressant treatment in a naturalistic setting.
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KEYWORD
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Chronotherapy major depressive disorder, Time of dose, Escitalopram, Treatment response, Insomnia
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